GDR 2905 - Neurosciences de la Mémoire
 Directeur: Serge Laroche
UMR 8195 - Université Paris Sud - Bât. 446, 91405 Orsay, France

Navigation, Mémoire et Vieillissement

Team 16 - Supervisor : Laure Rondi-Reig

Laboratory : Neurobiologie des Processus Adaptatifs, UMR CNRS 7102, Université Pierre & Marie Curie, 9 quai St Bernard, 75005 Paris. (Directeur : Jean Mariani)

Site : http://npa.snv.jussieu.fr
Contact : laure.rondi-reig@upmc.fr

Composition :
Laure Rondi-Reig (CR1 CNRS)
Christelle Rochefort (MC UPMC)
Christine Tobin (MC UPMC)
Aurélie Watilliaux (IE CNRS - Molecular and cellular approach)
Frédéric Jarlier (IE CNRS-bioinformatics)
Karim Benchenane (Postdoctoral fellow)
Céline Fouquet (Postdoctoral fellow)
Kinga Igloi (Postdoctoral fellow)
Virginie Delépine (PhD student)
Bénédicte Babayan (Master UPMC)
Julie Lefort (Master ENS Lyon)

Abstract of research works :
We aim to understand the neural bases of spatial memory and the possible causes of its progressive impairment during aging. Our research is divided in two complementary research topics 1) functional interaction between the different memory systems during information encoding and strategies selection during tasks of spatial navigation 2) interaction impairment between these memory systems and possible mechanisms of compensation during normal and pathological aging. We are particularly interested in functional loops involving interaction or competition between hippocampal and striatal memory systems or those involving the cerebellum (cerebello-thalamo-cortical loop). We do also study possible interaction between the cerebellar system involved in the motor control of action and the hippocampal system involved in mental representation of the environment during a task of spatial memory.

We combine innovating behavioral approaches, allowing a precise analysis of spatial navigation, with, cellular imaging and molecular biology and electrophysiology techniques in mice developed after conditional mutagenesis (knock-out, transgenic). We also enlarge our study to Human with tests directly adapted from animal, combining a behavioral approach with functional Magnetic Resonance Imaging (fMRI).

Choice of publications :
Selected publications
Fouquet C, Petit GH; Auffret, Gaillard, Rovira, Mariani J., Rondi-Reig L. (2009 on line), Early individual detection of age-related memory
Neurobiology of Aging, in press

Igloi K., Zaoui M., Berthoz A., Rondi-Reig L. (2009) Sequential egocentric strategy is acquired as early as allocentric strategy: parallel acquisition of these two navigation strategies",
Hippocampus, 19, 1199-1211 F1000 citation (Norman White) http://www.f1000biology.com/article/id/1159409

Benchenane K, Peyrache A, Khamassi M, Tierney P, Gioanni Y, Wiener SI, Battaglia FP. Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning.
Neuron, sous presse.

Girardeau G*, Benchenane K*, Wiener SI, Buzsáki G, Zugaro MB. Selective suppression of hippocampal ripples perturbes learning in a spatial reference memory task.
Nat. Neurosci, 2009 Oct;12(10):1222-23. * contribution égale des deux auteurs

Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C (2007) Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird basal Ganglia Nucleus Area X.
PloS Biol, 5(12):e321.

Rochefort C, He X, Scotto-Lomassese S, Scharff C (2007) Recruitment of FoxP2-expressing neurons to Area X varies during song development.
Developmental Neurobiology 67:809-817.

Benchenane K, Castel H, Boulouard M, Bluthé RM, Fernandez-Monreal M, Roussel BD, Lopez-Atalaya JP, Butt-Gueulle S, Agin V, Maubert E, Dantzer R, Touzani O, Dauphin F, Vivien D, Ali C. Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.
J Cell Sci. 2007 Feb 15;120(Pt 4):578-85.

Rochefort C, Lledo PM (2005) Short-term survival of newly generated neurons in the adult olfactory bulb after exposure to a complex environment.
Eur J Neurosci. 22:2863-2870.

Saghatelyan A, Roux P, Migliore M, Rochefort C, Desmaisons D, Charneau P, Shepherd GM, Lledo PM (2005) Activity-Dependent Adjustments of the Inhibitory Network in the Olfactory Bulb Following Early Postnatal Deprivation. Neuron 46:103-116.

Rochefort C, Gheusi G, Vincent JD, Lledo PM (2002) Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory.
J Neurosci. 22:2679-2689.

Rondi-Reig L., Petit G.H., Tobin C., Tonegawa S., Mariani J., Berthoz A. (2006), Impaired sequential-egocentric and allocentric memories in forebrain specific NMDA receptor knockout mice during a new task dissociating strategies of navigation.
J. Neuroscience, 26, 4071-4081

Burguière E., Arleo A., Hojjati MR, Elgersma Y, De Zeeuw C.I, Berthoz A., Rondi-Reig L.
Deficit during spatial navigation in mice lacking cerebellar LTD: a problem of motor adaptation rather than a problem of localization.
Nature Neuroscience, 8, 1292-1294 http://www2.cnrs.fr/presse/communique/762.htm

Nakazawa K., Sun L.D., Quirk M.C., Rondi-Reig L., Wilson M.A., Tonegawa S. (2003) Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron, 38, 305-315

Rondi-Reig L., Libbey M., Eichenbaum H. and Tonegawa S. (2001) CA1-specific N-methyl-D-aspartate receptor knock-out mice are deficient in solving a nonspatial transverse patterning task. Proc. Natnl. Acad. Sci. (USA), 98, 3543-3548

Technical pool :
Nous combinons et développons une approche comportementale permettant une analyse fine du comportement de navigation spatiale chez l'animal, en particulier chez des souris obtenues par mutagénèse conditionnelles (Knock-out, transgéniques) avec des approches d'imagerie cellulaire, de biologie moléculaire et electrophysiologiques en freely moving pendant la tâche comportementale. Nous réalisons également des études chez l'homme avec des tests directement adaptés de l'animal en combinant une approche comportementale avec de l'Imagerie par Résonnance Magnétique fonctionnelle (IRMf).